Monocyte-derived Extracellular Nampt-dependent Biosynthesis of Myocardial NAD+ Protects the Heart against Pressure Overload
نویسندگان
چکیده
منابع مشابه
Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-derived extracellular Nampt (eNampt), which is essential for hemodynamic compensation to pressure over...
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ژورنال
عنوان ژورنال: Journal of Cardiac Failure
سال: 2015
ISSN: 1071-9164
DOI: 10.1016/j.cardfail.2015.08.188